Monday, April 29, 2024

Calcium Carbonate, Calcium Phosphate, Dicalcium Phosphate, & Tricalcium Phosphate












CALCIUM CARBONATE
Calcium Carbonate is the carbonic salt of calcium.

Calcium Carbonate is a medication used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure that they are getting enough calcium (women who are pregnant, nursing or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium Carbonate is available under the following different brand names: Tums, Tums Chewy Delights, Tums Extra, Tums Freshers, Tums Kids, Tums Regular, Tums Smoothies, and Tums Ultra or Children's Pepto.

WHAT ARE SIDE EFFECTS ASSOCIATED WITH USING CALCIUM CARBONATE?

Common Side effects of Calcium Carbonate include:

  • Loss Of Appetite
  • Constipation
  • Gas (Flatulence)
  • Nausea
  • Vomiting
  • High Calcium Levels
  • Low Phosphate Levels
  • Milk-Alkali Syndrome

This document does not contain all possible side effects and others may occur. Check with your physician for additional information about side effects.

  • Calcium Carbonate has serious interactions with at least 21 different drugs.
  • Calcium Carbonate has moderate interactions with at least 127 different drugs.
  • Calcium Carbonate has minor interactions with at least 66 different drugs.

 

WHAT ARE WARNINGS AND PRECAUTIONS FOR CALCIUM CARBONATE?

Warnings

Translation content

This medication contains calcium carbonate. Do not take Tums, Tums Chewy Delights, Tums Extra, Tums Freshers, Tums Kids, Tums Regular, Tums Smoothies, Tums Ultra, or Children's Pepto if you are allergic to calcium carbonate or any ingredients contained in this drug.

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center immediately.

Contraindications

  • Hypersensitivity
  • High calcium levels in the urine
  • Kidney stones (renal calculi)
  • Low phosphate levels
  • High calcium levels
  • Suspected digoxin toxicity

 

WHAT IS CALCIUM CARBONATE AND HOW DOES IT WORK?

Calcium Carbonate is a medication used to prevent or treat low blood calcium levels in people who do not get enough calcium from their diets. It may be used to treat conditions caused by low calcium levels such as bone loss (osteoporosis), weak bones (osteomalacia/rickets), decreased activity of the parathyroid gland (hypoparathyroidism), and a certain muscle disease (latent tetany). It may also be used in certain patients to make sure that they are getting enough calcium (women who are pregnant, nursing or postmenopausal, people taking certain medications such as phenytoin, phenobarbital, or prednisone).

Calcium plays a very important role in the body. It is necessary for normal functioning of nerves, cells, muscle, and bone. If there is not enough calcium in the blood, then the body will take calcium from bones, thereby weakening bones. Having the right amount of calcium is important for building and keeping strong bones.

Calcium Carbonate is available under the following different brand names: Tums, Tums Chewy Delights, Tums Extra, Tums Freshers, Tums Kids, Tums Regular, Tums Smoothies, and Tums Ultra or Children's Pepto.

Osteoporosis affects about 44 million Americans over 50 years old, according to the National Osteoporosis Foundation, with 80 percent of women affected and 20 percent of men. Luckily, calcium carbonate can help prevent or reduce the effects of osteoporosis. However, complications and health problems can occur with calcium carbonate if you are not careful in how you take the supplements and which brand you buy.

Calcium Carbonate
A naturally occurring element, calcium carbonate exists in oyster shells, limestone and chalk, and becomes calcium supplements and antacids through manufacturing. According to MayoClinic.com, calcium carbonate contains 40 percent elemental calcium while the more refined calcium citrate contains 21 percent. Your calcium carbonate may or may not be combined with vitamin D or magnesium to help with absorption.

Toxicity
Because the U.S. Food and Drug Administration does not regulate dietary supplements, like vitamins and calcium supplements, some calcium carbonate brands may contain toxic metals, such as lead. Check the label on your supplement bottle for the words "purified" or "USP Verified Mark," which both indicate that the calcium has been tested.

Check with your doctor about how calcium carbonate might interact with other drugs you take. For example, the calcium may interfere with antibiotics, thyroid medicine, iron supplements or antacid medications. Other side effects include burping and excess gas, dry mouth, increased urination, loss of appetite and a metallic taste in your mouth.

CALCIUM PHOSPHATE
Calcium phosphate is a family of materials and minerals containing calcium ions (Ca2+) together with inorganic phosphate anions. Some so-called calcium phosphates contain oxide and hydroxide as well. Calcium phosphates are white solids of nutritious value[1] and are found in many living organisms, e.g., bone mineral and tooth enamel.[2] In milk, it exists in a colloidal form in micelles bound to casein protein with magnesium, zinc, and citrate–collectively referred to as colloidal calcium phosphate (CCP).[3] Various calcium phosphate minerals are used in the production of phosphoric acid and fertilizers. Overuse of certain forms of calcium phosphate can lead to nutrient-containing surface runoff and subsequent adverse effects upon receiving waters such as algal blooms and eutrophication.

https://en.wikipedia.org/wiki/Calcium_phosphate

Calcium phosphate is the calcium salt of phosphoric acid with widely used applications. Calcium phosphate is used to prevent and to treat calcium deficiencies. Calcium phosphate is typically available as an over the counter supplement or as an added ingredient in some toothpastes

DICALCIUM PHOSPHATE
Dicalcium phosphate is the calcium phosphate with the formula CaHPO4 and its dihydrate. The "di" prefix in the common name arises because the formation of the HPO42– anion involves the removal of two protons from phosphoric acid, H3PO4. It is also known as dibasic calcium phosphate or calcium monohydrogen phosphate. Dicalcium phosphate is used as a food additive, it is found in some toothpastes as a polishing agent and is a biomaterial.[1][2]

https://en.wikipedia.org/wiki/Dicalcium_phosphate

TRICALCIUM PHOSPHATE
Tricalcium phosphate is a calcium salt of phosphoric acid

Tricalcium phosphate is a calcium salt found in many nutritional supplements. Many people wonder about the safety of tricalcium phosphate, including side effects and whether it causes cancer.

What are the health risks?

Taking tricalcium phosphate may have a range of risks.

Hypercalcemia

One health risk of tricalcium phosphate is taking too much and developing hypercalcemia. Most often, the symptoms of high calcium levels are mild, but emergencies do occur, although this is rare.

However, it is important to note that someone would have to take a significant amount of tricalcium phosphate or have certain medical conditions to develop hypercalcemia.

The Cleveland Clinic Journal of Medicine reported on the case of an 80-year-old man, who went to the emergency room showing signs of hypercalcemia, including:

  • Constipation
  • Loss Of Appetite
  • Dry Mouth
  • Confusion 

Most of his blood work was normal, but his total serum calcium numbers were higher than they should be at 14.4 milligrams per deciliter (mg/dL). A healthy range is approximately 8.6 to 10.0 mg/dL.

The 80-year old had a variety of diseases, including diabetes, hypothyroidism, and hepatitis C that may have contributed to his hypercalcemic emergency.

Kidney Stones
Taking tricalcium phosphate may also increase the risk of developing kidney stones. One report from the Oregon State University suggests that the risk for kidney stones is higher in women who take calcium supplements and multivitamin supplements, though the overall evidence is conflicting.

Cardiovascular Problems
Several studies have reported an increased risk for cardiovascular events in people who take calcium supplements. One report in the journal, Australian Prescriber finds calcium supplements may increase the risk for heart attack by about 25 percent and the chance for stroke by up to 20 percent in women.

Tricalcium phosphate is not a good option for people with kidney disease.

When a person has kidney disease, their kidneys are unable to remove phosphorus effectively.

Tricalcium Phosphate and Cancer Risks

Researchers suggest that diets high in inorganic phosphates, which are additives found mostly in processed foods, such as meats and cheese, stimulate the growth of small cell cancers.

One study from the American Thoracic Society that studied mouse models reports that diets high in these phosphates may accelerate the growth of lung cancer tumors and contribute to tumor development in people who have an increased risk for lung cancer.

Other studies have found a connection between inorganic phosphates and the development of a variety of cancer types.

One Swedish study reported in BMC Cancer measured serum levels of inorganic phosphate (Pi) of people aged 20 years or older to assess cancer risk. The Swedish researchers found increasing Pi levels was a higher cancer risk in men, while in women, low levels of Pi were associated with higher risk of certain cancers.

Individuals, especially those with risk factors for different types of cancers and kidney disease, should talk to their doctor before taking any calcium supplement, including tricalcium phosphate.

The safest and most effective way to increase calcium intake and maintain calcium levels is by eating calcium-rich foods. Excellent sources of calcium include:

  • Tofu
  •  Leafy Greens, Kale, and Spinach
  • Soybeans
  • Which are often added to plant milk

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